Jung-Chi Liao

Adjunct Research Scientist
220 S. W. Mudd, Mail Code: 4703

Jung-Chi Liao is an assistant professor of mechanical engineering and biomedical engineering (affiliated) at Columbia University. He is also a member of Stem Cell Institute and Interdisciplinary Biosciences Program at Columbia University. He received his Ph.D. from MIT in 2002. His current research interests focus on dynamic studies of molecules in live cells. His lab extends the expertise in superresolution imaging and computational modeling and simulation to address dynamic problems in biology. Specifically, the research areas can be categorized into the following three directions: (1) dynamics of signaling activities in primary cilia of mammalian cells; (2) mechanobiology of induced pluripotent stem cells; and (3) structure-function relationship of molecular motors.  .

PhD, MS, and undergraduate research opportunities are available.

Recent Publications

Zhang, Y., Liao, J.-C. (2012) Identifying highly conserved and unique structural elements in myosin VI. Cellular and Molecular Bioengineering, in press.

Palla, M., Chen, C.-P., Zhang, Y., Li, J., Ju, J., Liao, J.-C. (2012) Mechanism of flexibility control for ATP access of hepatitis C virus NS3 helicase, Journal of Biomolecular Structure and Dynamics, in press.

Liao, J.-C. (2011) Mechanical transduction mechanisms of RecA-like molecular motors, Journal of Biomolecular Structure and Dynamics, 29, 497-507.

Elting, M.W., Bryant, Z., Liao, J.-C., Spudich, J.A. (2011) Detailed tuning of structure and intramolecular communication are dispensable for processive motion of myosin VI. Biophysical Journal, 100, 430-439.

Liao, J.-C., Elting, M.W., Delp, S.L., Spudich, J.A., Bryant, Z. (2009) Engineered myosin VI motors reveal minimal structural determinants of directionality and processivity. Journal of Molecular Biology, 392, 862-867.

Liao, J.-C., Spudich, J.A., Parker, D., Delp, S.L. (2007) Extending the absorbing boundary method to fit dwell-time distributions of molecular motors with complex kinetic pathways. Proceedings of the National Academy of Sciences, USA, 104, 3171-3716.

 Zheng, W., Liao, J.-C., Doniach, S., Brooks, B.R. (2007) Toward the mechanism of dynamical couplings in hepatitis C virus NS3 helicase using elastic network model. Proteins: Structure, Function, and Bioinformatics, 67, 886-896. 

Tang, S., Liao, J.-C., Dunn, A.R., Altman, R.B., Spudich, J.A., Schmidt, J.P. (2007) Predicting allosteric communication in myosin via a pathway of conserved residues. Journal of Molecular Biology, 373(5), 1361-1373. 

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